Construction of a risk signature for adrenocortical carcinoma using immune-related genes.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is considered a rare tumor with a dismal prognosis. Expression of immune-related genes (IRGs) in ACC and correlations between IRGs and ACC prognosis were assessed using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases.

Methods

To preliminarily predict immune cell infiltration, an immune score was calculated using ESTIMATE. Differentially expressed IRGs were screened, and potential biological functions were investigated. We then performed univariate Cox regression to identify IRGs associated with survival, and the regulatory mechanisms of IRGs associated with survival were predicted. We built a risk signature through multivariate Cox regression to evaluate patient overall survival (OS).

Results

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SUBMITTER: Fu Y 

PROVIDER: S-EPMC7658150 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature