A higher dose of vancomycin is needed in critically ill patients with augmented renal clearance.

ABSTRACT:

Background

Using standard vancomycin dosage in critically ill patients might lead to therapy failure and worse patient outcomes, augmented renal clearance (ARC) may be the leading risk factor. In this study, we comprehensively investigated the pharmacokinetics-pharmacodynamics (PK-PD) of vancomycin in critically ill patients with ARC, hoping to explore the precise and accurate dose adjustment method for vancomycin.

Methods

All critically ill patients tested for steady-state trough vancomycin serum concentrations during the recent 6 years in a tertiary level hospital were collected retrospectively and divided into ARC and non-ARC groups, respectively, according to creatinine clearance (CLcr). Serum vancomycin concentrations were measured by the fluorescence polarization immun

SUBMITTER: He J 

PROVIDER: S-EPMC7658164 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature