Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway.

ABSTRACT:

Background

Cartilage defects account for substantial economic and humanistic burdens and pose a significant clinical problem. The efficacy of clinical approaches to cartilage repair is often inadequate, in part, owing to the restricted proliferative capacity of chondrocytes. Molecules have the capacity to promote the differentiation of multipotent mesenchymal stem cells into chondrocytes and may also gain the ability to repair the damaged cartilage.

Objective

This study aimed to investigate the role of Atsttrin (progranulin-derived engineered protein) in cartilage repair as well as the signaling pathway involved.

Methods

Primary and mesenchymal stem cell lines were used for the micromass culture. A murine cartilage defect model was used to determine the role of Atsttr

SUBMITTER: Wei J 

PROVIDER: S-EPMC7658268 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature