Identifying Common Genes Related to Platelet and Immunity for Lung Adenocarcinoma Prognosis Prediction.

ABSTRACT:

Background

Although 1000s of immune-related and platelet receptor-related genes have been identified in lung adenocarcinoma, their role in prognosis prediction remains unclear.

Methods

We downloaded mRNA data from the Cancer Genome Atlas Dataset (TCGA), and GSE68465 or GSE14814 data sets from the Gene Expression Omnibus (GEO) database.

Results

The high-risk group's overall survival (OS) time was lower than that of the low-risk group's in TCGA (p = 1.15e-03). Additionally, the risk score was an independent prognostic survival factor for lung adenocarcinoma patients in TCGA (HR = 2.136, 95%CI = 1.553-2.937, p < 0.001). The model's prognostic performance was verified with two independent GEO cohorts (GSE68465 and GSE14814). We also developed a nomogram and

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7658298 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature