Correlation of tumor microenvironment from biopsy and resection specimens in untreated colorectal cancer patients: a surprising lack of agreement.

ABSTRACT:

Background

Colorectal cancer (CRC) tumor microenvironment (TME) characteristics, such as tumor infiltrating lymphocyte (TIL) densities and PD-L1 status, are predictive of recurrence, disease-free survival, and overall survival. In many malignancies, TME characteristics are also predictive of response to immunotherapy. As window of opportunity studies using neoadjuvant immunotherapy become more common and treatment guidelines incorporate TME features, accurate assessment of the pre-treatment TME using the biopsy specimen is critical. However, no study has thoroughly evaluated the correlation between the TMEs of the biopsy and resection specimens.

Methods

We conducted a retrospective analysis of patients with stage I-III CRC with matched biopsy and resection specimens. CD3+, C

SUBMITTER: Kemp Bohan PM 

PROVIDER: S-EPMC7658304 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature