Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice.

ABSTRACT:

Introduction

We previously demonstrated that magnesium ions (Mg²⁺) was a novel therapeutic alternative for osteoarthritis (OA) through promoting the hypoxia inducible factor-1α (HIF-1α)-mediated cartilage matrix synthesis. However, oxidative stress can inhibit the expression of HIF-1α, amplify the inflammation that potentially impairs the therapeutic efficacy of Mg²⁺ in OA. Vitamin (VC), a potent antioxidant, may enhance the efficacy of Mg²⁺ in OA treatment. This study aims to investigate the efficacy of combination of Mg²⁺ and VC on alleviating joint destruction and pain in OA.

Material and methods

Anterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular i

SUBMITTER: Yao H 

PROVIDER: S-EPMC7658330 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature