Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastoma.

ABSTRACT: Tumor-associated macrophages (TAMs) constitute up to 50% of tumor bulk in glioblastoma (GBM) and play an important role in tumor maintenance and progression. The recently discovered differences between invading tumour periphery and hypoxic tumor core implies that macrophage biology is also distinct by location. This may provide further insight into the observed treatment resistance to immune modulation. We hypothesize that macrophage activation occurs through processes that are distinct in tumor periphery versus core. We therefore investigated regional differences in TAM recruitment and evolution in GBM by combining open source single cell and bulk gene expression data. We used single cell gene expression data from 4 glioblastomas (total of 3589 cells) and 122 total bulk samples obtained f

SUBMITTER: Landry AP 

PROVIDER: S-EPMC7658345 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature