Antidepressant Use around Conception, Prepregnancy Depression, and Risk of Ectopic Pregnancy.

ABSTRACT:

Objective

To compare the risk of ectopic pregnancy among women with and women without antidepressant prescriptions around conception and examine whether this risk differs by prepregnancy depression status.

Methods

We conducted a cohort study of all pregnancies between November 1, 2008, and September 30, 2015, identified in the nationwide (American) IBM® MarketScan® Databases. At least one day's supply of antidepressants in the 3 weeks after a woman's last menstrual period defined active antidepressant use around conception. At least one depression diagnosis in the year before the last menstrual period defined prepregnancy depression. Relative risk (RR) of ectopic pregnancy was estimated using unadjusted and inverse probability of treatment (IPT)-weighted log-binomial models.

SUBMITTER: Wall-Wieler E 

PROVIDER: S-EPMC7658419 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature