Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe³⁺ as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer.

ABSTRACT: Hepatic cancer is a serious disease with high morbidity and mortality. Theranostic agents with effective diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer. Herein, we aimed to develop a novel mesoporous polydopamine (MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging (MRI)-guided cancer chemo-photothermal therapy. Superparamagnetic iron oxide (SPIO)-loaded MPDA NPs (MPDA@SPIO) was firstly prepared, followed by modifying with a targeted molecule of sialic acid (SA) and chelating with Fe³⁺ (SA-MPDA@SPIO/Fe³⁺ NPs). After that, doxorubicin (DOX)-loaded SA-MPDA@SPIO/Fe³⁺ NPs (SA-MPDA@SPIO/DOX/Fe³⁺) was prepared for tumor theranostics. The prepared SAPEG-MPDA@SPIO/Fe³⁺ NPs were w

SUBMITTER: Shu G 

PROVIDER: S-EPMC7658445 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature