Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response.

ABSTRACT: Related interleukin-2, -15, and -15-like (IL-2, -15, and -15L) are ancient cytokines, with all three genes surviving in extant fish and some mammals. The present study is the first to identify IL-15L functions, namely in rainbow trout. In isolated trout splenocytes, and in vivo, purified recombinant IL-15L+IL-15Rα molecules induced expression of IL-4 and IL-13 homologs, which are markers of type 2 immunity. In contrast, trout IL-15 stimulated type 1 immunity markers, thus IL-15 and IL-15L can have opposing functions. Trout IL-15L was more dependent on "in trans" presentation by the receptor chain IL-15Rα than IL-15, and stimulated CD4^-CD8^-(IgM^-) lymphocytes from thymus and spleen. We propose an important role for IL-15L early in

SUBMITTER: Yamaguchi T 

PROVIDER: S-EPMC7658486 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature