Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC7658493 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Yang Yang Y Li Wenhua W Wei Bochong B Wu Kai K Liu Donglei D Zhu Dengyan D Zhang Chunyang C Wen Fengbiao F Fan Yuxia Y Zhao Song S
Molecular therapy. Nucleic acids 20200916
Recent studies have suggested that microRNA let-7i is a tumor suppressor in human cancers, including esophageal cancer, but its underlying mechanism is not yet fully understood. We investigated the role and mechanisms of let-7i in the progression of esophageal cancer. We first showed that let-7i was downregulated in esophageal cancer tissues and cells and then linked its low expression to cancer progression. Bioinformatic analysis predicted KDM5B as a target gene of let-7i, which was confirmed b ...[more]