Molecular Profiling Reveals Common and Specific Development Processes in Different Types of Gynecologic Cancers.

ABSTRACT:

Background

Gynecologic cancers have become a major threat to women's health. The molecular biology of gynecologic cancers is not as well understood as that of breast cancer, and precision targeting is still new. Although viewed collectively as a group of cancers within the female reproductive system, they are more often studied separately. A comprehensive within-group comparison on molecular profiles is lacking.

Methods

We conducted a whole-exome sequencing study of cervical/endometrial/ovarian cancer samples from 209 Chinese patients. We combined our data with genomic and transcriptomic data from relevant TCGA cohorts to identify and verify common/exclusive molecular changes in cervical/endometrial/ovarian cancer.

Results

We identified shared molecular features inclu

SUBMITTER: Guo Y 

PROVIDER: S-EPMC7658613 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature