Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis.

ABSTRACT: Synthetic lethality is thought to play an important role in anticancer therapies. Herein, to understand the potential distributions and relationships between synthetic lethal interactions between genes, especially for pairs deriving from different sources, we performed an integrative analysis of genes at multiple molecular levels. Based on inter-species phylogenetic conservation of synthetic lethal interactions, gene pairs from yeast and humans were analyzed; a total of 37,588 candidate gene pairs containing 7,816 genes were collected. Of these, 49.74% of genes had 2-10 interactions, 22.93% were involved in hallmarks of cancer, and 21.61% were identified as core essential genes. Many genes were shown to have important biological roles via functional enrichment analysis, and 65 were identif

SUBMITTER: Guo L 

PROVIDER: S-EPMC7658657 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature