Risk and Prognosis of Secondary Rectal Cancer After Radiation Therapy for Pelvic Cancer.

ABSTRACT:

Background

The relationship between pelvic radiation therapy (RT) and second primary rectal cancer (SPRC) is unclear. The aim of this study was to assess the risk and prognosis of SPRC after pelvic RT.

Materials and methods

Data for patients who had primary pelvic cancer (PPC) between 1973 and 2016 were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Multiple primary standardized incidence ratios (SIRs) were used to assess the risk of SPRC. Five-year overall survival (OS) and rectal cancer-specific survival (RCSS) were calculated using Kaplan-Meier curves.

Results

A total of 573,306 PPC patients were included, 141,225 of whom had been treated with RT. Primary cancers were located in the prostate (50.83%), bladder (24.18%), corpus uterus

SUBMITTER: Yang R 

PROVIDER: S-EPMC7658675 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature