Identification of Prognosis-Related Genes in Bladder Cancer Microenvironment across TCGA Database.

ABSTRACT:

Background

Bladder cancer (BCa) is a common urothelial malignancy. The Cancer Genome Atlas (TCGA) database allows for an opportunity to analyze the relationship between gene expression and clinical outcomes in bladder cancer patients. This study is aimed at identifying prognosis-related genes in the bladder cancer microenvironment.

Methods

Immune scores and stromal scores were calculated by applying the ESTIMATE algorithm. We divided bladder cancer patients into high and low groups based on their immune/stromal scores. Then, differentially expressed genes (DEGs) were identified in bladder cancer patients based on the TCGA database. We evaluated the correlation between immune/stromal scores and clinical characteristics as well as prognosis. Finally, we validated identified ge

SUBMITTER: Zhao X 

PROVIDER: S-EPMC7658688 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature