Cerebral Microbleeds Are Associated with Loss of White Matter Integrity.

ABSTRACT:

Background and purpose

Previous studies have shown that diffusion tensor imaging suggests a diffuse loss of white matter integrity in people with white matter hyperintensities or lacunes. The purpose of this study was to investigate whether the presence of cerebral microbleeds and their distribution are related to the integrity of white matter microstructures.

Materials and methods

The study comprised 982 participants who underwent brain MR imaging to determine microbleed status. The cross-sectional relation between microbleeds and the microstructural integrity of the white matter was assessed by 2 statistical methods: a multilinear regression model based on the average DTI parameters of normal-appearing white matter and Tract-Based Spatial Statistics analysis, a tract-based

SUBMITTER: Liu JY 

PROVIDER: S-EPMC7658876 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature