Ontology highlight
ABSTRACT:
SUBMITTER: Das U
PROVIDER: S-EPMC7658950 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
ACS omega 20201102 44
We prepared a multimodality nanocomplex by functionalizing gold nanorods (GNRs) with a cytotoxic nucleoside, 5-fluoro-2'-deoxyuridine (FdU) containing a DNA hairpin, along with complexation of pleiotropic molecule curcumin. Conjugates were investigated for anti-tumor activity using an Ehrlich carcinoma model in combination with 808 nm laser irradiation. We demonstrated that hairpin-functionalized GNRs are suitable for intravenous administration, including delivery of cytotoxic nucleotides and cu ...[more]