Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population.

ABSTRACT: We performed a metabolome genome-wide association study for the Japanese population in the prospective cohort study of Tohoku Medical Megabank. By combining whole-genome sequencing and nontarget metabolome analyses, we identified a large number of novel associations between genetic variants and plasma metabolites. Of the identified metabolite-associated genes, approximately half have already been shown to be involved in various diseases. We identified metabolite-associated genes involved in the metabolism of xenobiotics, some of which are from intestinal microorganisms, indicating that the identified genetic variants also markedly influence the interaction between the host and symbiotic bacteria. We also identified five associations that appeared to be female-specific. A number of rare var

SUBMITTER: Koshiba S 

PROVIDER: S-EPMC7659008 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature