A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma.

ABSTRACT:

Background

Deregulation of the RNA polymerase III specific TFIIIB subunit BRF2 occurs in subtypes of human cancers. However, correlations between BRF2 alterations and clinical outcomes in breast cancer are limited. We conducted this review to analyze BRF2 alterations in genomic data sets housed in Oncomine and cBioPortal to identify potential correlations between BRF2 alterations and clinical outcomes.

Methods

The authors queried both Oncomine and cBioPortal for alterations in BRF2 in human cancers and performed meta-analyses identifying significant correlations between BRF2 and clinical outcomes in invasive breast cancer (IBC).

Results

A meta cancer outlier profile analysis (COPA) of 715 data sets (86,733 samples) in Oncomine identified BRF2 as overexpressed in 60% o

SUBMITTER: Cabarcas-Petroski S 

PROVIDER: S-EPMC7659115 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature