Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas.

ABSTRACT: Recent gene expression and copy number profilings of glioblastoma multiforme (GBM) by The Cancer Genome Atlas (TCGA) Research Network suggest the existence of distinct subtypes of this tumor. However, these approaches might not be easily applicable in routine clinical practice. In the current study, we aimed to establish a proteomics-based subclassification of GBM by integrating their genomic and epigenomic profiles. We subclassified 79 newly diagnosed GBM based on expression patterns determined by comprehensive immunohistochemical observation in combination with their DNA copy number and DNA methylation patterns. The clinical relevance of our classification was independently validated in TCGA datasets. Consensus clustering identified the four distinct GBM subtypes: Oligodendrocyte Precurs

SUBMITTER: Motomura K 

PROVIDER: S-EPMC7659188 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature