Genome-Wide Association Study for Urinary and Fecal Incontinence in Women.

ABSTRACT:

Purpose

Urinary incontinence and fecal incontinence are common disorders in women that negatively impact quality of life. In addition to known health and lifestyle risk factors, genetics may have a role in continence. Identification of genetic variants associated with urinary incontinence and fecal incontinence could result in a better understanding of etiologic pathways, and new interventions and treatments.

Materials and methods

We previously generated genome-wide single nucleotide polymorphism data from Nurses' Health Studies participants. The participants provided longitudinal urinary incontinence and fecal incontinence information via questionnaires. Cases of urinary incontinence (6,120) had at least weekly urinary incontinence reported on a majority of questionnaires (

SUBMITTER: Penney KL 

PROVIDER: S-EPMC7659982 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature