Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study.

ABSTRACT:

Objectives

To examine whether educational attainment and intelligence have causal effects on risk of Alzheimer's disease (AD), independently of each other.

Design

Two-sample univariable and multivariable Mendelian randomization (MR) to estimate the causal effects of education on intelligence and vice versa, and the total and independent causal effects of both education and intelligence on AD risk.

Participants

17 008 AD cases and 37 154 controls from the International Genomics of Alzheimer's Project (IGAP) consortium.

Main outcome measure

Odds ratio (OR) of AD per standardized deviation increase in years of schooling (SD = 3.6 years) and intelligence (SD = 15 points on intelligence test).

Results

There was strong evidence of a causal, bidirectional relat

SUBMITTER: Anderson EL 

PROVIDER: S-EPMC7660137 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature