Total Synthesis of Cyclopiamide A Using Palladium-Catalyzed Domino Cyclization.

ABSTRACT: Total synthesis of cyclopiamide A was accomplished using a palladium-catalyzed domino cyclization. Three rings in the tetracyclic skeleton of cyclopiamide A were constructed in a one-step domino reaction incorporating double carbopalladation and C-H activation.

SUBMITTER: Park S 

PROVIDER: S-EPMC7660198 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature