Chikungunya virus superinfection exclusion is mediated by a block in viral replication and does not rely on non-structural protein 2.

ABSTRACT: Superinfection exclusion (SIE) is a process by which a virally infected cell is protected from subsequent infection by the same or a closely related virus. By preventing cell coinfection, SIE favors preservation of genome integrity of a viral strain and limits its recombination potential with other viral genomes, thereby impacting viral evolution. Although described in virtually all viral families, the precise step(s) impacted by SIE during the viral life cycle have not been systematically explored. Here, we describe for the first time SIE triggered by chikungunya virus (CHIKV), an alphavirus of public health importance. Using single-cell technologies, we demonstrate that CHIKV excludes subsequent infection with: CHIKV; Sindbis virus, a related alphavirus; and influenza A, an unrelated RNA

SUBMITTER: Boussier J 

PROVIDER: S-EPMC7660575 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature