Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology.

ABSTRACT: Individual cells and epithelia control the chemical exchange with the surrounding environment by the fine-tuned expression, localization, and function of an array of transmembrane proteins that dictate the selective permeability of the lipid bilayer to small molecules, as actual gatekeepers to the interface with the extracellular space. Among the variety of channels, transporters, and pumps that localize to cell membrane, organic cation transporters (OCTs) are considered to be extremely relevant in the transport across the plasma membrane of the majority of the endogenous substances and drugs that are positively charged near or at physiological pH. In humans, the following six organic cation transporters have been characterized in regards to their respective substrates, all belonging to th

SUBMITTER: Samodelov SL 

PROVIDER: S-EPMC7660683 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature