Anticancer Therapy-Related Increases in Arterial Stiffness: A Systematic Review and Meta-Analysis.

ABSTRACT: Background Cardio-oncology is a clinical discipline focused primarily on the early detection of anticancer therapy-related cardiomyopathy. However, there is growing evidence that the direct adverse consequences extend beyond the myocardium to affect the vasculature, but this evidence remains limited. In addition, there remains a paucity of clinically based strategies for monitoring vascular toxicity in these patients. Importantly, arterial stiffness is increasingly recognized as a surrogate end point for cardiovascular disease and may be an important vascular outcome to consider. Therefore, the aim of this systematic review and meta-analysis was to summarize evidence of increased arterial stiffening with anticancer therapy and evaluate the effect of treatment modifiers. Methods and Results

SUBMITTER: Parr SK 

PROVIDER: S-EPMC7660726 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature