Bias and Loss to Follow-Up in Cardiovascular Randomized Trials: A Systematic Review.

ABSTRACT: Background Loss to follow-up (LTFU) is common in randomized controlled trials. However, its potential impact on primary outcomes from cardiovascular randomized controlled trials is not known. Methods and Results We conducted a prospective systematic review (PROSPERO: CRD42019121959) for randomized controlled trials published in 8 leading journals over 5 years from January 2014 to December 2018. Extent, reporting, and handling of LTFU data were recorded, and the proportion of a trial's primary outcome results that lose statistical significance was calculated after making plausible assumptions for the intervention and control arms. These assumptions could drive differential treatment effects between the groups considering relative event incidence between LTFU participants and those included

SUBMITTER: Fong LCW 

PROVIDER: S-EPMC7660731 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature