Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection.

ABSTRACT: Background Microvesicles are cell membrane-derived vesicles that have been shown to augment inflammation. Specifically, monocyte-derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus formation and cardiovascular disease. People living with HIV experience higher prevalence of cardiovascular disease and also exhibit increased levels of plasma microvesicles. The process of microvesicle release has striking similarity to budding of enveloped viruses. The surface protein tetherin inhibits viral budding by physically tethering budding virus particles to cells. Hence, we investigated the role of tetherin in regulating the release of MDMVs during HIV infection. Methods and Results The plasma of aviremic HIV-infected individuals had increased

SUBMITTER: Weber EA 

PROVIDER: S-EPMC7660781 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature