Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor.

ABSTRACT: Background The novel estrogen receptor, G-protein-coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt-induced complications, yet there is no direct evidence for GPER control of renal Na⁺ handling. We hypothesized that GPER activation in the renal medulla facilitates Na⁺ excretion. Methods and Results Herein, we show that infusion of the GPER agonist, G1, to the renal medulla increased Na⁺ excretion in female Sprague Dawley rats, but not male rats. We found that GPER mRNA expression and protein abundance were markedly higher in outer medullary tissues from females relative to males. Blockade of GPER in the renal medulla attenuated Na⁺ excret

SUBMITTER: Gohar EY 

PROVIDER: S-EPMC7660860 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature