Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death.

ABSTRACT:

Background

Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported.

Methods

We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm. Established electrogram criteria were used to identify the presence of structural alterations.

Results

VF occurred spontaneously in 3 patients and was induced in 16, whereas VF was noninducible in 5. VF mapping demonstrated reentrant and focal activities (87% versus 13%, respectively) in a

SUBMITTER: Haissaguerre M 

PROVIDER: S-EPMC7661047 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature