Combined stimuli of cold, hypoxia, and dehydration status on body temperature in rats: a pilot study with practical implications for humans.

ABSTRACT:

Objective

As human thermoregulatory responses to maintain core body temperature (T_core) under multiple stressors such as cold, hypoxia, and dehydration (e.g., exposure to high-altitude) are varied, the combined effects of cold, hypoxia, and dehydration status on T_core in rats were investigated. The following environmental conditions were constructed: (1) thermoneutral (24 °C) or cold (10 °C), (2) normoxia (21% O₂) or hypoxia (12% O₂), and (3) euhydration or dehydration (48 h water deprivation), resulted in eight environmental conditions [2 ambient temperatures (T_a) × 2 oxygen levels × 2 hydration statuses)]. Each condition lasted for 24 h.

Results

Normoxic conditions irrespective of hypoxia or dehydration did not strongl

SUBMITTER: Uno T 

PROVIDER: S-EPMC7661168 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature