Lectin complement pathway initiators after subarachnoid hemorrhage - an observational study.

ABSTRACT:

Background

This exploratory study investigated the time-course of lectin complement pathway (LCP) initiators in cerebrospinal fluid (CSF) and plasma in patients with subarachnoid hemorrhage (SAH), as well as their relationship to delayed cerebral ischemia (DCI) and functional outcome.

Methods

Concentrations of ficolin-1, ficolin-2, ficolin-3, and mannose-binding lectin (MBL) were analyzed in CSF and plasma from patients with SAH. Samples were collected daily from admission until day 9 (CSF; N__PATIENTS = 63, n__SAMPLES = 399) and day 8 (plasma; N__PATIENTS = 50, n__SAMPLES = 358), respectively. Twelve neurologically healthy patients undergoing spinal anesthesia and 12 healthy blood donors served as controls. The development of DCI duri

SUBMITTER: Matzen JS 

PROVIDER: S-EPMC7661172 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature