Modelling the household-level impact of a maternal respiratory syncytial virus (RSV) vaccine in a high-income setting.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) infects almost all children by the age of 2 years, with the risk of hospitalisation highest in the first 6 months of life. Development and licensure of a vaccine to prevent severe RSV illness in infants is a public health priority. A recent phase 3 clinical trial estimated the efficacy of maternal vaccination at 39% over the first 90 days of life. Households play a key role in RSV transmission; however, few estimates of population-level RSV vaccine impact account for household structure.

Methods

We simulated RSV transmission within a stochastic, individual-based model framework, using an existing demographic model, structured by age and household and parameterised with Australian data, as an exemplar of a high-income country. We m

SUBMITTER: Campbell PT 

PROVIDER: S-EPMC7661211 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature