Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness.

ABSTRACT:

Background

The spatial distribution and burden of dengue in sub-Saharan Africa remains highly uncertain, despite high levels of ecological suitability. The goal of this study was to describe the epidemiology of dengue among a cohort of febrile children presenting to outpatient facilities located in areas of western Uganda with differing levels of urbanicity and malaria transmission intensity.

Methods

Eligible children were first screened for malaria using rapid diagnostic tests. Children with a negative malaria result were tested for dengue using a combination NS1/IgM/IgG rapid test (SD Bioline Dengue Duo). Confirmatory testing by RT-PCR was performed in a subset of participants. Antigen-capture ELISA was performed to estimate seroprevalence.

Results

Only 6 of 1416 (0

SUBMITTER: Boyce RM 

PROVIDER: S-EPMC7661220 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature