Mutation bias can shape adaptation in large asexual populations experiencing clonal interference.

ABSTRACT: The extended evolutionary synthesis invokes a role for development in shaping adaptive evolution, which in population genetics terms corresponds to mutation-biased adaptation. Critics have claimed that clonal interference makes mutation-biased adaptation rare. We consider the behaviour of two simultaneously adapting traits, one with larger mutation rate U, the other with larger selection coefficient s, using asexual travelling wave models. We find that adaptation is dominated by whichever trait has the faster rate of adaptation v in isolation, with the other trait subject to evolutionary stalling. Reviewing empirical claims for mutation-biased adaptation, we find that not all occur in the 'origin-fixation' regime of population genetics where v is only twice as s

SUBMITTER: Gomez K 

PROVIDER: S-EPMC7661309 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature