Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation.

ABSTRACT: The force-length relation is one of the most defining features of muscle contraction, and yet a topic of debate in the literature. The sliding filament theory predicts that the force produced by muscle fibres is proportional to the degree of overlap between myosin and actin filaments, producing a linear descending limb of the active force-length relation. However, several studies have shown forces that are larger than predicted, especially at long sarcomere lengths (SLs). Studies have been conducted with muscle fibres, preparations containing thousands of sarcomeres that make measurements of individual SL challenging. The aim of this study was to evaluate force production and sarcomere dynamics in isolated myofibrils and single sarcomeres from the rabbit psoas muscle to enhance our underst

SUBMITTER: Haeger R 

PROVIDER: S-EPMC7661311 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature