Discontinuing antidepressant medication after mindfulness-based cognitive therapy: a mixed-methods study exploring predictors and outcomes of different discontinuation trajectories, and its facilitators and barriers.

ABSTRACT:

Objectives

This study aimed to explore predictors and outcomes associated with different trajectories of discontinuing antidepressant medication (ADM), in recurrently depressed individuals after participation in mindfulness-based cognitive therapy (MBCT). Facilitators and barriers of discontinuation were explored qualitatively.

Design

Mixed-methods study combining quantitative and qualitative data, drawn from a randomised controlled trial.

Setting

Twelve secondary and tertiary psychiatric outpatient clinics in the Netherlands.

Participants

Recurrently depressed individuals (N=226) who had been using ADM for at least 6 months and in partial or full remission. Regardless of trial condition, we made post-hoc classifications of patients' actual discontinuati

SUBMITTER: Huijbers MJ 

PROVIDER: S-EPMC7661362 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature