Efficacy and safety profile of statins in patients with cancer: a systematic review of randomised controlled trials.

ABSTRACT:

Purpose

A growing body of preclinical and observational research suggests that statins have potential as a therapeutic strategy in patients with cancer. This systematic review of randomised controlled trials (RCTs) in patients with solid tumours aimed to determine the efficacy of statin therapy on mortality outcomes, their safety profile and the risk of bias of included studies.

Methods

Full-text articles comparing statin therapy versus control in solid tumours and reporting mortality outcomes were identified from Medline and Embase from conception to February 2020. A systematic review with qualitative (primarily) and quantitative synthesis was conducted. This systematic review was prospectively registered (Prospero registration CRD42018116364).

Results

Eleven trials

SUBMITTER: Thomas JP 

PROVIDER: S-EPMC7661422 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature