Developmental divergence of sensory stimulus representation in cortical interneurons.

ABSTRACT: Vasocative-intestinal-peptide (VIP⁺) and somatostatin (SST⁺) interneurons are involved in modulating barrel cortex activity and perception during active whisking. Here we identify a developmental transition point of structural and functional rearrangements onto these interneurons around the start of active sensation at P14. Using in vivo two-photon Ca²⁺ imaging, we find that before P14, both interneuron types respond stronger to a multi-whisker stimulus, whereas after P14 their responses diverge, with VIP⁺ cells losing their multi-whisker preference and SST⁺ neurons enhancing theirs. Additionally, we find that Ca²⁺ signaling dynamics increase in precision as the cells and network mature. Rabies virus tracings followed by tis

SUBMITTER: Kastli R 

PROVIDER: S-EPMC7661508 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature