Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs.

ABSTRACT: Structural studies of challenging targets such as G protein-coupled receptors (GPCRs) have accelerated during the last several years due to the development of new approaches, including small-wedge and serial crystallography. Here, we describe the deposition of seven datasets consisting of X-ray diffraction images acquired from lipidic cubic phase (LCP) grown microcrystals of two human GPCRs, Cysteinyl leukotriene receptors 1 and 2 (CysLT₁R and CysLT₂R), in complex with various antagonists. Five datasets were collected using small-wedge synchrotron crystallography (SWSX) at the European Synchrotron Radiation Facility with multiple crystals under cryo-conditions. Two datasets were collected using X-ray free electron laser (XFEL) serial femtosecond crystallography (SFX)

SUBMITTER: Marin E 

PROVIDER: S-EPMC7661540 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature