Current Applications of Growth Factors for Knee Cartilage Repair and Osteoarthritis Treatment.

ABSTRACT:

Purpose of review

The decreased contact area, edge loading, and increased stress in the adjacent area cartilage resulting from chondral defects are believed to predispose this tissue to degenerative changes that have significant economic implications, especially when considering its progression to osteoarthritis of the knee. Growth factors are considered therapeutic possibilities to enhance healing of chondral injuries and modify the progression to degenerative arthritis. Thus, the purposes of this review are to first to summarize important points for defect preparation and recent advances in techniques for marrow stimulation and second, and to identify specific growth factors and cytokines that have the capacity to advance cartilage regeneration and the treatment of osteoarthritis

SUBMITTER: Shah SS 

PROVIDER: S-EPMC7661573 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature