COVID-19 and Systemic Lupus Erythematosus: Focus on Immune Response and Therapeutics.

ABSTRACT: The SARS-CoV-2 novel coronavirus has caused the COVID-19 pandemic with over 35 million cases and over a million deaths worldwide as of early October 2020. The populations most affected are the elderly and especially those with underlying comorbidities. In terms of race and ethnicity, black and hispanic populations are affected at disproportionately higher rates. Individuals with underlying conditions that cause an immune-compromised state are considered vulnerable to this infection. The immune response is an important determinant in viral infections including coronaviruses, not only in the antiviral defense but also in the disease progression, severity, and clinical outcomes of COVID-19. Systemic lupus erythematosus is a chronic autoimmune disease which also disproportionately afflicts bla

SUBMITTER: Spihlman AP 

PROVIDER: S-EPMC7661632 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature