Associating Type 2 Diabetes Risk Factor Genes and FDG-PET Brain Metabolism in Normal Aging and Alzheimer's Disease.

ABSTRACT: Background: Several studies have linked type 2 diabetes (T2D) to an increased risk of developing Alzheimer's disease (AD). This has led to an interest in using antidiabetic treatments for the prevention of AD. However, the underlying mechanisms explaining the relationship between T2D and AD have not been completely elucidated. Objective: Our objective was to examine cerebral ¹⁸F-fluorodeoxyglucose (FDG) uptake during normal aging and in AD patients in regions associated with diabetes genetic risk factor expression to highlight which genes may serve as potential targets for pharmaceutical intervention. Methods: We calculated regional glucose metabolism differences in units of standardized uptake values (SUVR) for 386 cognitively healthy adults and 335 clinica

SUBMITTER: Nugent S 

PROVIDER: S-EPMC7661639 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature