Injectable Biologics for the Treatment of Degenerative Disc Disease.

ABSTRACT:

Purpose of review

Spinal pain and associated disability is a leading cause of morbidity worldwide that has a strong association with degenerative disc disease (DDD). Biologically based therapies to treat DDD face significant challenges posed by the unique milieu of the environment within the intervertebral disc, and many promising therapies are in the early stages of development. Patient selection, reasonable therapeutic goals, approach, and timing will need to be discerned to successfully translate potential therapeutics. This review provides a brief overview of the status of intradiscal biologic therapies.

Recent findings

Proposed systemic delivery of therapeutic agents has not progressed very much in large part due to the risk of adverse events in remote tissues plus the

SUBMITTER: Matta A 

PROVIDER: S-EPMC7661671 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature