Disruption of Streptococcus mutans and Candida albicans synergy by a commensal streptococcus.

ABSTRACT: Polymicrobial interactions in dental plaque play a significant role in dysbiosis and homeostasis in the oral cavity. In early childhood caries, Streptococcus mutans and Candida albicans are often co-isolated from carious lesions and associated with increased disease severity. Studies have demonstrated that metabolic and glucan-dependent synergism between C. albicans and S. mutans contribute to enhanced pathogenesis. However, it is unclear how oral commensals influence pathogen synergy. Streptococcus parasanguinis, a hydrogen peroxide (H₂O₂) producing oral commensal, has antimicrobial activity against S. mutans. In this study, we utilized a three species biofilm model to understand the impact of S. parasanguinis on S. mutans and C. albicans synergy. We report that S. p

SUBMITTER: Huffines JT 

PROVIDER: S-EPMC7661713 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature