A Praziquantel Treatment Study of Immune and Transcriptome Profiles in Schistosoma haematobium-Infected Gabonese Schoolchildren.

ABSTRACT:

Background

Although Schistosoma haematobium infection has been reported to be associated with alterations in immune function, in particular immune hyporesponsiveness, there have been only few studies that have used the approach of removing infection by drug treatment to establish this and to understand the underlying molecular mechanisms.

Methods

Schistosoma haematobium-infected schoolchildren were studied before and after praziquantel treatment and compared with uninfected controls. Cellular responses were characterized by cytokine production and flow cytometry, and in a subset of children RNA sequencing (RNA-Seq) transcriptome profiling was performed.

Results

Removal of S haematobium infection resulted in increased schistosome-specific cytokine responses that were n

SUBMITTER: Labuda LA 

PROVIDER: S-EPMC7661769 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature