A comprehensive pan-cancer study of fibroblast growth factor receptor aberrations in Chinese cancer patients.

ABSTRACT:

Background

The prevalence and types of fibroblast growth factor receptor (FGFR) mutations vary significantly among different ethnic groups. The optimal application of FGFR inhibitors depends on these variations being comprehensively understood. However, such an analysis has yet to be conducted in Chinese patients.

Methods

We retrospectively screened the genomic profiling results of 10,582 Chinese cancer patients across 16 cancer types to investigate the frequency and distribution of FGFR aberrations.

Results

FGFR aberrations were identified in 745 patients, equating to an overall prevalence of 7.0%. A majority of the aberrations occurred on FGFR1 (56.8%), which was followed by FGFR3 (17.7%), FGFR2 (14.4%), and FGFR4 (2.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC7661893 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature