Modeling Lung Derecruitment in VILI Due to Fluid-Occlusion: The Role of Emergent Behavior.

ABSTRACT: Ventilator-induced lung injury (VILI) is driven by the processes of volutrauma and atelectrauma, which can act synergistically to compromise the blood-gas barrier. We have postulated that this synergy arises through a rich-get-richer mechanism whereby atelectrauma causes holes to form in the blood-gas barrier while concomitant volutrauma causes susceptible holes to progressively enlarge as VILI worsens. We previously developed an analytical model based on this idea that accurately predicts the progressive increases in lung elastance seen immediately following a recruitment maneuver as VILI progresses over the course of hours. In the present study we extend this model to account for the rate of change of elastance, due to closure of lung units, in the minutes following a recruitment maneuve

SUBMITTER: Mori V 

PROVIDER: S-EPMC7662071 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature