JS-MA: A Jensen-Shannon Divergence Based Method for Mapping Genome-Wide Associations on Multiple Diseases.

ABSTRACT: Taking advantage of the high-throughput genotyping technology of Single Nucleotide Polymorphism (SNP), Genome-Wide Association Studies (GWASs) have been successfully implemented for defining the relative role of genes and the environment in disease risk, assisting in enabling preventative and precision medicine. However, current multi-locus-based methods are insufficient in terms of computational cost and discrimination power to detect statistically significant interactions with different genetic effects on multifarious diseases. Statistical tests for multi-locus interactions (≥2 SNPs) raise huge analytical challenges because computational cost increases exponentially as the growth of the cardinality of SNPs in an interaction module. In this paper, we develop a simple, fast, and powerful m

SUBMITTER: Guo X 

PROVIDER: S-EPMC7662082 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature