Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19.

ABSTRACT:

Objectives

The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild-to-moderate-presenting patients and severely affected patients. Variation in immune response to SARS-CoV-2 may underlie this clinical variation.

Methods

Using a high-dimensional systems immunology platform, we have analysed the peripheral blood compartment of 6 healthy individuals, 23 mild-to-moderate and 20 severe COVID-19 patients.

Results

We identify distinct immunological signatures in the peripheral blood of the mild-to-moderate and severe COVID-19 patients, including T-cell lymphopenia, more consistent with peripheral hypo- than

SUBMITTER: Neumann J 

PROVIDER: S-EPMC7662088 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature